Synthesis and Biological Evaluation of α-Tocopherol Derivatives as Potential Anticancer Agents

α-Tocopheryl succinate (α-TS) and α-tocopheryloxyacetic acid (α-TEA) are potent inducers of apoptosis in cancer cells efficient suppressors tumors experimental model cell lines. They exhibit selective cytotoxicity against tumor very limited or no toxicity toward nonmalignant cells. In the present work, a series new α-tocopherol derivatives were synthesized as analogs α-TS α-TEA. The cytotoxic activity obtained compounds was tested using three human lines, including chronic lymphoblastic leukemia (CEM), breast adenocarcinoma (MCF7), cervical (HeLa), normal fibroblasts (BJ). introduction an alkyl substituent into ether-linked acetic moiety α-TEA increased anticancer activity. α-Tocopheryloxy-2-methylpropanoic with two additional geminal methyl groups more active CEM compared to non-toxic order acquire deeper understanding biological compounds, molecular docking study also conducted. Our research confirmed that vitamin E interesting valuable terms their potential therapeutic use agents.